Evaluation of Hemostatic Effectiveness in a Standard Swine Hemorrhage Model of Severe Bleeding: A Comparative Study of Chitosan Gauze and Kaolin Gauze

Superior Hemostasis Efficacy and Improvement of Survival Rate

• In this preclinical study, swine carotid artery is transecting by 50% resulting in a grade IV bleeding (blood loss of 100 mL/min).
• Axiostat gauze significantly reduce the post treatment blood loss by more than 80% as compared to Kaolin gauze (P<0.05). Axiostat gauze also demonstrated 100 % survival rate and improves the survival rate by 67% than kaolin gauze.

Antimicrobial Efficacy of Axiostat Gauze

• After 24 hours of contact time, Axiostat gauze showed more than 99.99% reduction of viable microorganisms against all the pathogenic microbial strains that causes bleeding wound infection. Kaolin gauze has no antimicrobial property.

Microscopic Analysis:

Visually there is no disperse particulate matter observed in the extract of Axiostat Gauze at predetermined time point while dispersed particles were observed in the extract of kaolin gauze which Indicates that it releases the kaolin particles that can cause embolism.

Turbidimetry Analysis:

In the turbidimetry analysis using uv spectrometry, it is observed that kaolin gauze shows significantly higher turbidity compared to Axiostat Gauze over the period which indicates that kaolin gauze releases the particles.