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A randomised controlled trial comparing a 100% chitosan haemostatic dressing and a manual compression device following transradial coronary intervention

Publication Details

Pandey CB, Garg N, Kapoor A, Tewari S, Khanna R, Sahu A, Khare H, Katheria A, Nazir A, Jaiswal A. A randomised controlled trial comparing a 100% chitosan haemostatic dressing and a manual compression device following transradial coronary intervention. AsiaIntervention. 2026 Oct 23;12(3):218.

Key Findings

  • To compare the safety and efficacy of Axiostat® with Terumo TR band in achieving radial access site haemostasis following Transradial Coronary Intervention (TRCI).

Core Results

1. Time to Haemostasis

  • Rapid Haemostasis: Axiostat achieved a mean haemostasis time of 5.84 minutes compared with 120.2 minutes with Terumo TR Band.

2. Radial Artery Occlusion

  • No radial artery occlusion (RAO) events were observed in the Axiostat group, compared with 3.12% in the Terumo TR Band group.

3. Rebleeding Incidence

  • Lower Rebleeding rate was reported in 0.77% of patients in the Axiostat® group versus 2.34% in the Terumo TR Band group, despite the shorter compression time of Axiostat. 

Key Insights & Discussion

  1. Faster haemostasis: Axiostat® achieved haemostasis in a mean of 5.84 minutes compared with 120.2 minutes with the manual compression device.
  2. Lower radial artery occlusion (RAO): No RAO events were observed in the Axiostat group, compared with 3.12% in the Terumo TR Band group.
  3. Low rebleeding and Haematoma incidence: Axiostat® group showed decreased haematoma and rebleeding incidence, compared with the Terumo TR Band group, along with its low compression time.
  4. Good patient tolerability: Post-application pain scores were low and comparable between groups.
  5. Favourable safety profile: No serious adverse events, allergic reactions, or device-related complications were reported in either group.
Conclusion: Axiostat® appear to provide an effective and safe alternative to conventional manual compression approaches, enabling rapid haemostasis, shorter compression duration, absence of observed radial artery occlusion, lower patient-reported discomfort, and minimal postprocedural complications following transradial coronary interventions.
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